Effects Of 2 - Methvl - 3 - ~ ropvnvlauinazolin - 4 - ( 3 H ) - one On Vascular Reactivitv In Isolated Porcine Tail Arteries
نویسنده
چکیده
The vascular effects of 2-methyl-3-propynylquinazolin-4-(3H)-one (QUIN) have been studied on isolated porcine tail arteries. QUlN had no effect on resting tension but relaxed, dose-dependently, arteries precontracted with noradrenaline or high-K' in the order: NA > high-K'. Also, QUlN inhibited both intracellular (ICD) and extracellular (ECD) Ca2'-dependent contractions in the order: ICD > ECD The results suggest that QUlN interferes with vascular ca2' mobilization.
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تاریخ انتشار 2017